Inflammatory bowel disease (Crohn disease) 1
OMIM:266600Mode of inheritance:Multifactorial
Disease classification:Diseases of the digestive system
Polymorphisms
| Gene symbol | NOD2 |
|---|
| Reference transcript | NM_022162.1 |
|---|
| DNA Change | c.2722G>C |
|---|
| A.A. Change | p.Gly908Arg |
|---|
| Exon/Intron | exon 8 |
|---|
| Variation Type | substitution |
|---|
| Cases | 101 patients with CD (59 women/ 42 men) |
|---|
| Controls | 107 healthy controls ( 55 men and 52 women) |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| Gly | 189 (93.57%) | 208 (97.2%) | | | | Arg | 13 (6.43%) | 06 (2.80%) | 2.37 (0.823-7.793) | 0.099 | | Gly/Gly | 90 (89.2%) | 101 (94.4%) | | | | Gly/Arg | 9 (8.91%) | 6 (50.60%) | | | | Arg/Arg | 2 (1.98%) | 0 | | |
|
|---|
| Comments | No association of NOD2/p.Gly908Arg variant with Crohns disease. |
|---|
| Reference | Hama I, Ratbi I, Reggoug S, Elkerch F, Kharrasse G, Errabih I, Ouazzani H, Sefiani A.
Non-association of Crohns disease with NOD2 gene variants in Moroccan patients.
Gene. 2012 May 10;499(1):121-3. |
|---|
| Gene symbol | NOD2 |
|---|
| Reference transcript | NM_022162.1 |
|---|
| DNA Change | c.2722G>C |
|---|
| A.A. Change | p.Gly908Arg |
|---|
| Exon/Intron | exon 8 |
|---|
| Variation Type | substitution |
|---|
| Cases | 69 with Crohn’s disease |
|---|
| Controls | 114 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 97.1% | 99.1% | 1 | | | C | 2.9% | 0.9% | 3.37 (0.61-18.67) | 0.16 | | GG | 94.2% | 98.2% | 1 | | | GC | 5.8% | 1.8% | 3.45 (0.61-19.34) | 0.16 |
|
|---|
| Reference | Serbati N, Badre W, Diakite B, Nadifi S.NOD2/CARD15 gene influences disease behaviour but not IBD susceptibility in a Moroccan population.
Turk J Gastroenterol. 2014 Dec;25 Suppl 1:122-8. |
|---|
| Gene symbol | NOD2 |
|---|
| Reference transcript | NM_022162.1 |
|---|
| DNA Change | c.3017_3018insC |
|---|
| A.A. Change | p.Leu1007ProfsX2 |
|---|
| Exon/Intron | exon 11 |
|---|
| Variation Type | insertion |
|---|
| Reference SNP | rs5743293 |
|---|
| Cases | 101 patients with CD ( (59 women/ 42 men)) |
|---|
| Controls | 107 healthy controls ( 55 men and 52 women) |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| WT | 200 (99.01%) | 214 (100%) | | | | MT | 02 (0.99%) | 0 | INF (0.199-INF) | | | WT/WT | 99(98.02%) | 107(100%) | | | | WT/MT | 2(1.98%) | 0 | | | | MT/MT | 0 | 0 | | |
|
|---|
| Comments | No association of NOD2/p.Leu1007fsinsC variant with Crohns disease |
|---|
| Reference | Hama I, Ratbi I, Reggoug S, Elkerch F, Kharrasse G, Errabih I, Ouazzani H, Sefiani A.
Non-association of Crohns disease with NOD2 gene variants in Moroccan patients.
Gene. 2012 May 10;499(1):121-3. |
|---|
| Gene symbol | NOD2 |
|---|
| Reference transcript | NM_022162.1 |
|---|
| DNA Change | c.3017_3018insC |
|---|
| A.A. Change | p.Leu1007ProfsX2 |
|---|
| Exon/Intron | exon 11 |
|---|
| Variation Type | insertion |
|---|
| Reference SNP | rs5743293 |
|---|
| Cases | 69 with Crohn’s disease |
|---|
| Controls | 114 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| WT | 98.6% | 99.6% | 1 | | | MT | 1.4% | 0.4% | 0.34 (0.30-37.16) | 0.33 | | WT/WT | 97.1% | 99.1% | 1 | | | WT/MT | 2.9% | 0.9% | 3.37 (0.30-37.91) | 0.32 |
|
|---|
| Reference | Serbati N, Badre W, Diakite B, Nadifi S.NOD2/CARD15 gene influences disease behaviour but not IBD susceptibility in a Moroccan population.
Turk J Gastroenterol. 2014 Dec;25 Suppl 1:122-8. |
|---|
| Gene symbol | NOD2 |
|---|
| Reference transcript | NM_022162.1 |
|---|
| DNA Change | c.2104C>T |
|---|
| A.A. Change | p.Arg702Trp |
|---|
| Exon/Intron | exon 4 |
|---|
| Variation Type | substitution |
|---|
| Cases | 101 patients with CD ( (59 women/ 42 men)) |
|---|
| Controls | 107 healthy controls ( 55 men and 52 women) |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| Arg | 201 (99.51%) | 213 (99.54%) | | | | Trp | 01 (0.49%) | 01 (0.46%) | 1.059 (0.013-83.516) | | | Arg/Arg | 100 (99%) | 106 (99.07%) | | | | Arg/Trp | 1 (1%) | 1 (0.93%) | | | | Trp/Trp | 0 | 0 | | |
|
|---|
| Comments | No association of NOD2/p.Arg702Trp variants with Crohns disease |
|---|
| Reference | Hama I, Ratbi I, Reggoug S, Elkerch F, Kharrasse G, Errabih I, Ouazzani H, Sefiani A.
Non-association of Crohns disease with NOD2 gene variants in Moroccan patients.
Gene. 2012 May 10;499(1):121-3. |
|---|
| Gene symbol | NOD2 |
|---|
| Reference transcript | NM_022162.1 |
|---|
| DNA Change | c.2104C>T |
|---|
| A.A. Change | p.Arg702Trp |
|---|
| Exon/Intron | exon 4 |
|---|
| Variation Type | substitution |
|---|
| Cases | 27 with ulcerative colitis |
|---|
| Controls | 114 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 97.8% | 95.6% | 1 | | | T | 2.2% | 4.4% | 0.48 (0.13-1.79) | 0.28 | | CC | 95.7% | 92.1% | 1 | | | CT | 4.3% | 7% | 0.60 (0.15-2.33) | 0.46 | | TT | 0% | 0.9% | 0.52 (0.02-13.17 | 0.70 |
|
|---|
| Reference | Serbati N, Badre W, Diakite B, Nadifi S.NOD2/CARD15 gene influences disease behaviour but not IBD susceptibility in a Moroccan population.
Turk J Gastroenterol. 2014 Dec;25 Suppl 1:122-8. |
|---|
| Gene symbol | NOD2 |
|---|
| Reference transcript | NM_022162.1 |
|---|
| DNA Change | c.2104C>T |
|---|
| A.A. Change | p.Arg702Trp |
|---|
| Exon/Intron | exon 4 |
|---|
| Variation Type | substitution |
|---|
| Cases | 69 with Crohn’s disease |
|---|
| Controls | 114 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 98.1% | 95.6% | 1 | | | T | 1.9% | 4.4% | 0.4 (0.05-3.28) | 0.40 | | CC | 96.3% | 92.1% | 1 | | | CT | 3.7% | 7% | 0.50 (0.06-4.21) | 0.53 | | TT | 0% | 0.9% | 1.33 (0.05-33.51) | 0.86 |
|
|---|
| Reference | Serbati N, Badre W, Diakite B, Nadifi S.NOD2/CARD15 gene influences disease behaviour but not IBD susceptibility in a Moroccan population.
Turk J Gastroenterol. 2014 Dec;25 Suppl 1:122-8. |
|---|
| Gene symbol | NOD2 |
|---|
| Reference transcript | NM_022162.1 |
|---|
| DNA Change | c.2105G>C |
|---|
| A.A. Change | p.Arg702Pro |
|---|
| Exon/Intron | exon4 |
|---|
| Variation Type | substitution |
|---|
| Cases | 101 patients with CD ( (59 women/ 42 men)) |
|---|
| Controls | 107 healthy controls ( 55 men and 52 women) |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 5 (1.9%) | 5 (1.9%) | | |
|
|---|
| Comments | No association was observed |
|---|
| Reference | Hama I, Ratbi I, Reggoug S, Elkerch F, Kharrasse G, Errabih I, Ouazzani H, Sefiani A.
Non-association of Crohns disease with NOD2 gene variants in Moroccan patients.
Gene. 2012 May 10;499(1):121-3. |
|---|
| Gene symbol | NOD2 |
|---|
| Reference transcript | NM_022162.1 |
|---|
| DNA Change | c.2753C>A |
|---|
| A.A. Change | p.Ala918Asp |
|---|
| Exon/Intron | exon8 |
|---|
| Variation Type | substitution |
|---|
| Cases | 101 patients with CD ( (59 women/ 42 men)) |
|---|
| Controls | 107 healthy controls ( 55 men and 52 women) |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 201 (99.5%) | 214 (100%) | | | | A | 1 (0.5%) | 0 | | |
|
|---|
| Comments | No association was observed. |
|---|
| Reference | Hama I, Ratbi I, Reggoug S, Elkerch F, Kharrasse G, Errabih I, Ouazzani H, Sefiani A.
Non-association of Crohns disease with NOD2 gene variants in Moroccan patients.
Gene. 2012 May 10;499(1):121-3. |
|---|
| Gene symbol | TLR4 |
|---|
| Reference transcript | NM_138554.4 |
|---|
| DNA Change | c.896A>G |
|---|
| A.A. Change | p.Asp299Gly |
|---|
| Exon/Intron | exon 3 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs4986790 |
|---|
| Cases | 83 with Crohn’s disease |
|---|
| Controls | 112 |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 5.4% | 4.5% | 1.23 (0.49-3.09) | 0.66 | | AG | 10.8% | 7.1% | 1.57 (0.58-4.25) | 0.38 |
|
|---|
| Reference | Senhaji N, Diakité B, Serbati N, Zaid Y, Badre W, Nadifi S.Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis.
BMC Gastroenterol. 2014 Dec 10;14:206. |
|---|
| Gene symbol | TLR4 |
|---|
| Reference transcript | NM_138554.4 |
|---|
| DNA Change | c.896A>G |
|---|
| A.A. Change | p.Asp299Gly |
|---|
| Exon/Intron | exon 3 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs4986790 |
|---|
| Cases | 34 with ulcerative colitis |
|---|
| Controls | 112 |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 8.8% | 4.5% | 2.07 (0.72-5.92) | 0.17 | | AG | 17.6% | 7.1% | 2.76 (0.88-8.61) | 0.08 |
|
|---|
| Reference | Senhaji N, Diakité B, Serbati N, Zaid Y, Badre W, Nadifi S.Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis.
BMC Gastroenterol. 2014 Dec 10;14:206. |
|---|
| Gene symbol | TLR4 |
|---|
| Reference transcript | NM_138554.4 |
|---|
| DNA Change | c.1196C>T |
|---|
| A.A. Change | p.Thr399Ile |
|---|
| Exon/Intron | exon 3 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs4986791 |
|---|
| Cases | 83 with Crohn’s disease |
|---|
| Controls | 112 |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 4.2% | 1.3% | 3.24 (0.83-12.74) | 0.09 | | CT | 8.4% | 2.7% | 3.35 (0.84-13.35) | 0.09 |
|
|---|
| Reference | Senhaji N, Diakité B, Serbati N, Zaid Y, Badre W, Nadifi S.Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis.
BMC Gastroenterol. 2014 Dec 10;14:206. |
|---|
| Gene symbol | TLR4 |
|---|
| Reference transcript | NM_138554.4 |
|---|
| DNA Change | c.1196C>T |
|---|
| A.A. Change | p.Thr399Ile |
|---|
| Exon/Intron | exon 3 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs4986791 |
|---|
| Cases | 34 with ulcerative colitis |
|---|
| Controls | 112 |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 4.4% | 1.3% | 3.4 (0.67-17.25) | 0.14 | | CT | 2.9% | 2.7% | 1.14 (0.11-11.29) | 0.91 | | TT | 2.9% | - | 10.11 (0.40-254.1) | 0.16 |
|
|---|
| Reference | Senhaji N, Diakité B, Serbati N, Zaid Y, Badre W, Nadifi S.Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis.
BMC Gastroenterol. 2014 Dec 10;14:206. |
|---|
| Gene symbol | MTHFR |
|---|
| Reference transcript | NM_005957.4 |
|---|
| DNA Change | c.665C>T (C677T) |
|---|
| A.A. Change | p.Ala222Val |
|---|
| Exon/Intron | exon 4 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1801133 |
|---|
| Cases | 68 with Crohn’s disease |
|---|
| Controls | 182 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 69.9% | 72.8% | 1 | | | T | 30.1% | 27.2% | 1.16 (0.75-1.78) | 0.51 | | CC | 48.5% | 51.6% | 1 | | | CT | 42.6% | 42.83% | 1.07 (0.60-1.92) | 0.81 | | TT | 8.8% | 6.0% | 1.55 (0.53-4.53) | 0.42 |
|
|---|
| Reference | Senhaji N, Serbati N, Diakité B, Arazzakou S, Hamzi K, Badre W, Nadifi S.Methylenetetrahydrofolate reductase C677T variant in Moroccan patients with inflammatory bowel disease.
Gene. 2013 May 25;521(1):45-9. |
|---|
| Gene symbol | MTHFR |
|---|
| Reference transcript | NM_005957.4 |
|---|
| DNA Change | c.665C>T (C677T) |
|---|
| A.A. Change | p.Ala222Val |
|---|
| Exon/Intron | exon 4 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1801133 |
|---|
| Cases | 28 with ulcerative colitis |
|---|
| Controls | 182 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 78.6% | 72.8% | 1 | | | T | 21.4% | 27.2% | 0.73 (0.37-1.44) | 0.36 | | CC | 60.7% | 51.6% | 1 | | | CT | 35.7% | 42.83% | 0.72 (0.31-1.66) | 0.44 | | TT | 3.6% | 6.0% | 0.50 (0.06-4.15) | 0.52 |
|
|---|
| Reference | Senhaji N, Serbati N, Diakité B, Arazzakou S, Hamzi K, Badre W, Nadifi S.Methylenetetrahydrofolate reductase C677T variant in Moroccan patients with inflammatory bowel disease.
Gene. 2013 May 25;521(1):45-9. |
|---|
| Gene symbol | MIF |
|---|
| Reference transcript | NM_002415.1 |
|---|
| DNA Change | c.-270G>C |
|---|
| A.A. Change | |
|---|
| Exon/Intron | 5' of the ATG codon |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs755622 |
|---|
| Cases | 199 IBD patients |
|---|
| Controls | 311 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 103 | 160 | | | | G | 295 | 456 | 1.00 (0.75-1.33) | 0.97 | | CC | 9 (4.52%) | 22 (7.14%) | | | | CG | 85 (42.71%) | 116 (37.66%) | 1.10 (0.77-1.57) (Dominant) | 0.59 | | GG | 105 (52.76%) | 170 (55.19%) | 0.61 (0.27-1.36) (Recessive) | 0.23 |
|
|---|
| Reference | Senhaji N, Serrano A, Badre W, Serbati N, Karkouri M, Zaid Y, Nadifi S, Martin J.
Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort.
Genes Immun. 2016 Jan-Feb;17(1):60-5. doi: 10.1038/gene.2015.52. Epub 2015 Dec 3. |
|---|
| Gene symbol | TNF |
|---|
| Reference transcript | NM_000594.3 |
|---|
| DNA Change | c.-488G>A |
|---|
| A.A. Change | |
|---|
| Exon/Intron | 5' of the ATG codon |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1800629 |
|---|
| Cases | 199 IBD patients |
|---|
| Controls | 311 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| A | 81 | 103 | | | | G | 317 | 513 | 1.27 (0.92-1.76) | 0.14 | | AA | 15 (7.54%) | 6 (1.95%) | | | | AG | 51 (25.63%) | 91 (29.55%) | 1.07 (0.73-1.57) (Dominant) | 0.69 | | GG | 133 (66.83%) | 211 (68.51%) | 4.10 (1.56-10.76) (Recessive) | 0.004 |
|
|---|
| Reference | Senhaji N, Serrano A, Badre W, Serbati N, Karkouri M, Zaid Y, Nadifi S, Martin J.
Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort.
Genes Immun. 2016 Jan-Feb;17(1):60-5. doi: 10.1038/gene.2015.52. Epub 2015 Dec 3. |
|---|
| Gene symbol | IL6 |
|---|
| Reference transcript | NM_000600.4 |
|---|
| DNA Change | c.324+147C>G |
|---|
| A.A. Change | |
|---|
| Exon/Intron | intron 3 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs2069840 |
|---|
| Cases | 199 IBD patients |
|---|
| Controls | 311 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| GG | 11 (5.64%) | 19 (6.38%) | | | | GC | 67 (34.36%) | 113 (37.92%) | 1.83 (0.58-1.21) (Dominant) | 0.34 | | CC | 117 (60.00%) | 166 (55.70%) | 0.87 (0.40-1.88) (Recessive) | 0.73 |
|
|---|
| Reference | Senhaji N, Serrano A, Badre W, Serbati N, Karkouri M, Zaid Y, Nadifi S, Martin J.
Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort.
Genes Immun. 2016 Jan-Feb;17(1):60-5. doi: 10.1038/gene.2015.52. Epub 2015 Dec 3. |
|---|
| Gene symbol | IL6R |
|---|
| Reference transcript | NM_000565.3 |
|---|
| DNA Change | c.1073A>C |
|---|
| A.A. Change | p.Asp358Ala |
|---|
| Exon/Intron | exon 9 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs2228145 |
|---|
| Cases | 199 IBD patients |
|---|
| Controls | 311 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| CC | 20 (10.15%) | 33 (10.89%) | | | | CA | 85 (43.15%) | 125 (41.25%) | 1.04 (0.73-1.5) (Dominant) | 0.80 | | AA | 92 (46.70%) | 145 (47.85%) | 0.92 (0.51-1.66) (Recessive) | 0.79 |
|
|---|
| Reference | Senhaji N, Serrano A, Badre W, Serbati N, Karkouri M, Zaid Y, Nadifi S, Martin J.
Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort.
Genes Immun. 2016 Jan-Feb;17(1):60-5. doi: 10.1038/gene.2015.52. Epub 2015 Dec 3. |
|---|
| Gene symbol | IL6ST |
|---|
| Reference transcript | NM_001190981.1 |
|---|
| DNA Change | c.442G>C |
|---|
| A.A. Change | p.Gly148Arg |
|---|
| Exon/Intron | exon 5 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs2228044 |
|---|
| Cases | 199 IBD patients |
|---|
| Controls | 311 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| CC | 9 (4.64%) | 15 (4.82%) | | | | CG | 58 (29.90%) | 109 (35.05%) | 0.79 (0.54-1.15) (Dominant) | 0.22 | | GG | 127 (65.46%) | 187 (60.13%) | 0.96 (0.41-2.23) (Recessive) | 0.92 |
|
|---|
| Reference | Senhaji N, Serrano A, Badre W, Serbati N, Karkouri M, Zaid Y, Nadifi S, Martin J.
Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort.
Genes Immun. 2016 Jan-Feb;17(1):60-5. doi: 10.1038/gene.2015.52. Epub 2015 Dec 3. |
|---|
| Gene symbol | IL17A |
|---|
| Reference transcript | NM_002190.2 |
|---|
| DNA Change | c.-197G>A |
|---|
| A.A. Change | |
|---|
| Exon/Intron | 5' of the ATG codon |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs2275913 |
|---|
| Cases | 199 IBD patients |
|---|
| Controls | 311 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| GG | 5 (2.75%) | 10 (3.46%) | | | | GA | 48 (26.37%) | 74 (25.61%) | 1.00 (0.66-1.50) (Dominant) | 0.98 | | AA | 129 (70.88%) | 205 (70.93%) | 0.78 (0.26-2.34) (Recessive) | 0.66 |
|
|---|
| Reference | Senhaji N, Serrano A, Badre W, Serbati N, Karkouri M, Zaid Y, Nadifi S, Martin J.
Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort.
Genes Immun. 2016 Jan-Feb;17(1):60-5. doi: 10.1038/gene.2015.52. Epub 2015 Dec 3. |
|---|
| Gene symbol | IL17A |
|---|
| Reference transcript | NM_002190.2 |
|---|
| DNA Change | c.-877A>G |
|---|
| A.A. Change | |
|---|
| Exon/Intron | 5' of the ATG codon |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs4711998 |
|---|
| Cases | 199 IBD patients |
|---|
| Controls | 311 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| GG | 32 (17.58%) | 44 (15.22%) | | | | GA | 77 (42.31%) | 132 (45.67%) | 0.95 (0.65-1.40) (Dominant) | 0.82 | | AA | 73 (40.11%) | 113 (39.10%) | 1.18 (0.72-1.95) (Recessive) | 0.49 |
|
|---|
| Reference | Senhaji N, Serrano A, Badre W, Serbati N, Karkouri M, Zaid Y, Nadifi S, Martin J.
Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort.
Genes Immun. 2016 Jan-Feb;17(1):60-5. doi: 10.1038/gene.2015.52. Epub 2015 Dec 3. |
|---|
| Gene symbol | IL17A |
|---|
| Reference transcript | NM_002190.2 |
|---|
| DNA Change | c.*159G>A |
|---|
| A.A. Change | |
|---|
| Exon/Intron | 3' of the stop codon |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs7747909 |
|---|
| Cases | 199 IBD patients |
|---|
| Controls | 311 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| AA | 2 (1.10%) | 6 (2.08%) | | | | AG | 50 (27.47%) | 67 (23.18%) | 1.18 (0.78-1.79) (Dominant) | 0.42 | | GG | 130 (71.43%) | 216 (74.74%) | 0.52 (0.1-2.62) (Recessive) | 0.43 |
|
|---|
| Reference | Senhaji N, Serrano A, Badre W, Serbati N, Karkouri M, Zaid Y, Nadifi S, Martin J.
Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort.
Genes Immun. 2016 Jan-Feb;17(1):60-5. doi: 10.1038/gene.2015.52. Epub 2015 Dec 3. |
|---|
| Gene symbol | IL17A |
|---|
| Reference transcript | NM_002190.2 |
|---|
| DNA Change | c.-737C>T |
|---|
| A.A. Change | |
|---|
| Exon/Intron | 3' of the stop codon |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs8193036 |
|---|
| Cases | 199 IBD patients |
|---|
| Controls | 311 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| CC | 6 (3.30%) | 15 (5.19%) | | | | CT | 63 (34.62%) | 111 (38.41%) | 0.78 (0.54-1.15) (Dominant) | 0.22 | | TT | 113 (62.09%) | 163 (56.40%) | 0.62 (0.23-1.63) (Recessive) | 0.33 |
|
|---|
| Reference | Senhaji N, Serrano A, Badre W, Serbati N, Karkouri M, Zaid Y, Nadifi S, Martin J.
Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort.
Genes Immun. 2016 Jan-Feb;17(1):60-5. doi: 10.1038/gene.2015.52. Epub 2015 Dec 3. |
|---|
| Gene symbol | IL17A |
|---|
| Reference transcript | NM_002190.2 |
|---|
| DNA Change | c.-444A>G |
|---|
| A.A. Change | |
|---|
| Exon/Intron | 3' of the stop codon |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs3819024 |
|---|
| Cases | 199 IBD patients |
|---|
| Controls | 311 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| GG | 6 (3.30%) | 20 (6.92%) | | | | GA | 60 (32.97%) | 88 (30.45%) | 0.95 (0.64-1.40) (Dominant) | 0.80 | | AA | 116 (63.74%) | 181 (62.63%) | 0.45 (0.18-1.16) (Recessive) | 0.10 |
|
|---|
| Reference | Senhaji N, Serrano A, Badre W, Serbati N, Karkouri M, Zaid Y, Nadifi S, Martin J.
Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort.
Genes Immun. 2016 Jan-Feb;17(1):60-5. doi: 10.1038/gene.2015.52. Epub 2015 Dec 3. |
|---|