MIF

Gene name: n macrophage migration inhibitory factor (glycosylation-inhibiting factor)
OMIM ID: 153620
Chromosome location: 22q11.23

Polymorphisms

Disease/Phenotype	Mycobacterium tuberculosis, susceptibility to
Reference transcript	NM_002415.1
DNA Change	c.-270G>C
A.A. Change
Exon/Intron	5' of the ATG codon
Variation Type	substitution
Reference SNP	rs755622
Cases	123 patients with PTB
Controls	154 healthy controls
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value G 159 (64.63%) 227 (73.7%) 0.65 (0.450.95) 0.02 C 87 (35.37%) 81 (26.3%) 1.53 (1.052.24) 0.02 GG 21 (17.07%) 9(5.84%) 0.003 GC 45 (36.59%) 36 (40.90%) 0.46 CC 57 (46.34%) 82 (53.25%) 3.32 (1.378.19) 0.25
Comments	Statistically significant increase was found of the MIF ?173CC and MIF ?173C allele frequencies in PTB patients compared with healthy controls,
Reference	Sadki K, Lamsyah H, Rueda B, Akil E, Sadak A, Martin J, El Aouad R. Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population. J Genet Genomics. 2010 Apr;37(4):257-64.

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Disease/Phenotype	Inflammatory bowel disease (Crohn disease) 1
Reference transcript	NM_002415.1
DNA Change	c.-270G>C
A.A. Change
Exon/Intron	5' of the ATG codon
Variation Type	substitution
Reference SNP	rs755622
Cases	199 IBD patients
Controls	311 healthy controls
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value C 103 160 G 295 456 1.00 (0.75-1.33) 0.97 CC 9 (4.52%) 22 (7.14%) CG 85 (42.71%) 116 (37.66%) 1.10 (0.77-1.57) (Dominant) 0.59 GG 105 (52.76%) 170 (55.19%) 0.61 (0.27-1.36) (Recessive) 0.23
Reference	Senhaji N, Serrano A, Badre W, Serbati N, Karkouri M, Zaid Y, Nadifi S, Martin J. Association of inflammatory cytokine gene polymorphisms with inflammatory bowel disease in a Moroccan cohort. Genes Immun. 2016 Jan-Feb;17(1):60-5. doi: 10.1038/gene.2015.52. Epub 2015 Dec 3.

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