Diabetes mellitus, type 2 (T2DM), susceptibility to
OMIM:125853Mode of inheritance:Multifactorial
Disease classification:Endocrine, nutritional and metabolic disease
Polymorphisms
| Gene symbol | MTHFR |
|---|
| Reference transcript | NM_005957.4 |
|---|
| DNA Change | c.665C>T |
|---|
| A.A. Change | p.Ala222Val |
|---|
| Exon/Intron | exon 4 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1801133 |
|---|
| Cases | 282 diabetic patients |
|---|
| Controls | 262 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 417 (73.93%) | 350 (66.79%) | 1 | | | T | 147 (26.06%) | 174 (33.20%) | 0.70 (0.54-0.95) | 0.009 | | CC | 106 (56.74%) | 114 (43.51%) | | | | CT | 97 (34.90%) | 122 (46.56%) | | | | TT | 25 (8.87%) | 26 (9.92%) | | |
|
|---|
| Comments | An evident association between the MTHFR C677T polymorphism and T2DM in Moroccan patients. |
|---|
| Reference | Benrahma H, Abidi O, Melouk L, Ajjemami M, Rouba H, Chadli A, Oudghiri M, Farouqui A, Barakat A.
Association of the C677T Polymorphism in the Human Methylenetetrahydrofolate Reductase (MTHFR) Gene with the Genetic Predisposition for Type 2 Diabetes Mellitus in a Moroccan Population.
Genet Test Mol Biomarkers. 2012 May;16(5):383-7. |
|---|
| Gene symbol | MTHFR |
|---|
| Reference transcript | NM_005957.4 |
|---|
| DNA Change | c.1286A>C |
|---|
| A.A. Change | p.Glu429Ala |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1801131 |
|---|
| Cases | 282 diabetic patients |
|---|
| Controls | 262 healthy controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| A | 451 (79.96%) | 394 (75.19%) | 1 | | | C | 113 (20.0%) | 130 (24.81%) | 0.75 (0.57-1.01) | 0.058 | | AA | 180 (63.83%) | 147 (56.10%) | | | | AC | 91 (32.27%) | 100 (38.17%) | | | | CC | 11 (3.90%) | 15 (5.73%) | | |
|
|---|
| Comments | No significant association with the MTHFR
polymorphism and T2DM in Moroccan patients. |
|---|
| Reference | Benrahma H, Abidi O, Melouk L, Ajjemami M, Rouba H, Chadli A, Oudghiri M, Farouqui A, Barakat A.
Association of the C677T Polymorphism in the Human Methylenetetrahydrofolate Reductase (MTHFR) Gene with the Genetic Predisposition for Type 2 Diabetes Mellitus in a Moroccan Population.
Genet Test Mol Biomarkers. 2012 May;16(5):383-7. |
|---|
| Gene symbol | BCL11A |
|---|
| Reference transcript | NC_000002.11 |
|---|
| DNA Change | g.60584819G>A |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs243021 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normogly-caemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| A | 57.4% | 55.7% | 1.25 (1.03-1.54) | 0.02 (Recessive) |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | ADAMTS9 |
|---|
| Reference transcript | NC_000003.11 |
|---|
| DNA Change | g.64705365C>T |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs6795735 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 32.3 % | 31.8% | 1.06 (0.92-1.22) | 0.45 (Log-additive) |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | ADAMTS9 |
|---|
| Reference transcript | NC_000003.11 |
|---|
| DNA Change | g.64711904C>T |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs4607103 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 64.7% | 62.6% | 1.22 (1.01-1.47) | 0.04 (Recessive) |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | IGF2BP2 |
|---|
| Reference transcript | NC_000003.11 |
|---|
| DNA Change | g.185529080A>C |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1470579 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 46.4% | 42.4% | 1.17 (1.03-1.34) | 0.01(Log-additive) |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | WFS1 |
|---|
| Reference transcript | NM_001145853.1 |
|---|
| DNA Change | c.461-9A>G |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs10010131 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 72.6% | 69.6% | Log-additive:1.18 (1.00-1.37) | 0.05 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | CDKAL1 |
|---|
| Reference transcript | NM_017774.3 |
|---|
| DNA Change | c.371+30101A>G |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs7756992 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 33.2% | 31.1% | Recessive: 1.40 (1.04-1.88) | 0.03 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | TP53INP1 |
|---|
| Reference transcript | NC_000008.10 |
|---|
| DNA Change | g.95960511T>C |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs896854 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 56% | 53.1% | Recessive: 1.19 (0.97-1.45) | 0.09 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | CDKN2A |
|---|
| Reference transcript | NT_008413.18 |
|---|
| DNA Change | g.22124094T>C |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs10811661 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 84.6% | 82.4% | Log-additive: 1.18 (1.00-1.41) | 0.05 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | CDKN2B |
|---|
| Reference transcript | NC_000009.11 |
|---|
| DNA Change | g.22029547T>A |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs564398 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 79.9% | 77.7% | Log-additive: 1.16 (0.99-1.35) | 0.06 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | TCF7L2 |
|---|
| Reference transcript | NM_001146274.1 |
|---|
| DNA Change | c.450+33966C>T |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs7903146 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 47.6% | 38.5% | Log-additive: 1.47 (1.29-1.66) | 4.06 ? 10− 9 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | TCF7L2 |
|---|
| Reference transcript | NM_001146274.1 |
|---|
| DNA Change | c.450+33966C>T |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs7903146 |
|---|
| Cases | 504 T2D subjects |
|---|
| Controls | 406 normoglycemic |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| CC | 140 (27.13%) | 176 (42.41%) | | | | CT | 277 (53.67%) | 185 (44.58%) | | | | TT | 99 (19.18%) | 54 (13.01%) | | |
|
|---|
| Comments | An evident association between the TCF7L2 rs7903146 T allele and T2D. The allelic odds ratio (OR) was 1.56 [1.29?1.89] (p=2.9?10-6) |
|---|
| Reference | Cauchi S, El Achhab Y, Choquet H, Dina C, Krempler F, Weitgasser R, Nejjari C, Patsch W, Chikri M, Meyre D, Froguel P.TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis.
J Mol Med (Berl). 2007 Jul;85(7):777-82. |
|---|
| Gene symbol | KCNQ1 |
|---|
| Reference transcript | NM_000218.2 |
|---|
| DNA Change | c.1514+8160A>G |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs231362 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 54.9% | 53.2% | Dominant : 1.23 (0.98-1.54) | 0.07 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | KCNQ1 |
|---|
| Reference transcript | NM_000218.2 |
|---|
| DNA Change | c.1795-19467A>C |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs2283228 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| A | 95.1% | 94.6% | Dominant : 1.72 (0.32-9.09) | 0.53 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | HNF1A |
|---|
| Reference transcript | NM_003733.2 |
|---|
| DNA Change | c.1047+1107A>T |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs7957197 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 85.1% | 81.6% | Log-additive: 1.27 (1.06-1.49) | 0.01 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | FTO |
|---|
| Reference transcript | NM_001080432.2 |
|---|
| DNA Change | c.46-43098T>C |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1421085 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 39.5% | 35.6% | Log-additive: 1.18 (1.04-1.35) | 0.01 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | MC4R |
|---|
| Reference transcript | NC_000018.9 |
|---|
| DNA Change | g.57851097T>C |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs17782313 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 19.5% | 16.9% | Log-additive: 1.18 (1.00-1.39) | 0.05 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | GCK |
|---|
| Reference transcript | NG_008847.1 |
|---|
| DNA Change | g.4955G>A |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1799884 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| A | 20.6% | 18.1% | Dominant: 1.24 (1.02-1.50) | 0.03 |
|
|---|
| Comments | Polymorphism associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | NOTCH2 |
|---|
| Reference transcript | NC_000001.10 |
|---|
| DNA Change | g.120517959G>T |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs10923931 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 14.1 | 12.9 | Recessive: 1.41 (0.76-2.64) | 0.27 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | THADA |
|---|
| Reference transcript | NC_000002.11 |
|---|
| DNA Change | g.43618819C>T |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs11899863 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 94.3% | 93.6% | Recessive: 1.19 (0.89-1.61) | 0.23 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | THADA |
|---|
| Reference transcript | NC_000002.11 |
|---|
| DNA Change | g.43732823T>C |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs7578597 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 92.5% | 91.2 | Log-additive: 1.20 (0.94-1.52) | 0.13 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | IRS1 |
|---|
| Reference transcript | NT_005403.17 |
|---|
| DNA Change | g.77303163T>C |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs2943641 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 58.6% | 58.1% | Dominant: 1.12 (0.88-1.45) | 0.34 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | PPARG |
|---|
| Reference transcript | NG_011749.1 |
|---|
| DNA Change | g.68777C>G |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1801282 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 95.7% | 95.3% | Recessive: 1.14 (0.82-1.59) | 0.43 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | ZBED3 |
|---|
| Reference transcript | NC_000005.9 |
|---|
| DNA Change | g.76424949G>A |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs4457053 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 26.7% | 26.5% | Recessive: 0.92 (0.63-1.34) | 0.66 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | JAZF1 |
|---|
| Reference transcript | NC_000007.13 |
|---|
| DNA Change | g.28180556T>C |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs864745 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 54.1% | 51.9% | Log-additive: 1.08 (0.94-1.22) | 0.29 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | CDC123 |
|---|
| Reference transcript | NC_000010.10 |
|---|
| DNA Change | g.12328010A>G |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs12779790 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 21.0% | 20.4% | Dominant: 1.12 (0.93-1.35) | 0.24 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | HHEX |
|---|
| Reference transcript | NC_000010.10 |
|---|
| DNA Change | g.94462882C>T |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1111875 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 67.3% | 67.0% | Dominant: 1.1 (0.83-1.45) | 0.49 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | CENTD2 |
|---|
| Reference transcript | NM_001040118.2 |
|---|
| DNA Change | c.509+4567T>A |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1552224 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| A | 94.6% | 95.8% | Log-additive: 0.78 (0.53-1.15) | 0.20 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | MTNR1B |
|---|
| Reference transcript | NC_000011.9 |
|---|
| DNA Change | g.92673828C>T |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1387153 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 23.0% | 22.8% | Recessive: 1.15 (0.76-1.72) | 0.51 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | HMGA2 |
|---|
| Reference transcript | NC_000012.11 |
|---|
| DNA Change | g.66174894G>C |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1531343 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 26.3% | 26.7% | Recessive: 0.87 (0.62-1.22) | 0.42 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | TSPAN8 |
|---|
| Reference transcript | NC_000012.11 |
|---|
| DNA Change | g.71663102C>T |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs7961581 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 26.9% | 27.5% | Dominant: 0.90 (0.75-1.08) | 0.25 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | PRC1 |
|---|
| Reference transcript | NM_003981.3 |
|---|
| DNA Change | c.1107+1051G>A |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs8042680 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| A | 50.5% | 48.9% | Recessive: 1.14 (0.93-1.40) | 0.22 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | HNF1B |
|---|
| Reference transcript | NM_000458.2 |
|---|
| DNA Change | c.545-2701A>T |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs757210 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 37.2% | 37.6% | Recessive: 0.80 (0.61?1.06) | 0.12 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | HNF1B |
|---|
| Reference transcript | NM_000458.2 |
|---|
| DNA Change | g.36098040G>A |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs4430796 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 66.5% | 65.4% | Dominant: 1.10 (0.81-1.47) | 0.55 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | GCKR |
|---|
| Reference transcript | NM_001486.3 |
|---|
| DNA Change | c.1337T>C |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1260326 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 57.4% | 55.8% | Recessive: 1.16 (0.96-1.41) | 0.11 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | ENPP1 |
|---|
| Reference transcript | NM_006208.2 |
|---|
| DNA Change | c.517A>C |
|---|
| A.A. Change | p.Lys173Gln |
|---|
| Exon/Intron | exon 6 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1044498 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 38.0% | 37.1% | Dominant: 1.08 (0.90-1.31) | 0.41 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | ADIPOQ |
|---|
| Reference transcript | NG_021140.1 |
|---|
| DNA Change | g.4012C>G |
|---|
| A.A. Change | |
|---|
| Variation Type | others |
|---|
| Reference SNP | rs266729 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 23.0% | 23.4% | Recessive: 1.12 (0.76-1.65) | 0.56 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | KLHDC5 |
|---|
| Reference transcript | NM_020782.1 |
|---|
| DNA Change | c.1066+24G>A |
|---|
| A.A. Change | |
|---|
| Exon/Intron | Intron |
|---|
| Variation Type | others |
|---|
| Reference SNP | rs2288232 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| A | 61.2% | 61.4% | Dominant: 1.08 (0.83-1.39) | 0.59 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | CFB |
|---|
| Reference transcript | NM_001710.5 |
|---|
| DNA Change | c.450A>G |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1048709 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 90.6% | 91.1% | Log-additive: 0.95 (0.76-1.19) | 0.66 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | KCNJ11 |
|---|
| Reference transcript | NC_000011.8 |
|---|
| DNA Change | g.17366148T>C |
|---|
| A.A. Change | E23K |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs5219 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| T | 27.7% | 27.1% | Dominant: 1.04 (0.86-1.26) | 0.66 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | KCNJ11 |
|---|
| Reference transcript | NC_000011.8 |
|---|
| DNA Change | g.17366148T>C |
|---|
| A.A. Change | E23K |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs5219 |
|---|
| Cases | 250 |
|---|
| Controls | 250 |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| E | 80.44% | 79% | 1 | | | K | 19.56% | 21% | 0.90 (0.66-1.23) | 0.52 | | EE | 64.11% | 63% | 1 | | | EK | 32.66% | 32% | 1.29 (0.77-2.19) | 0.327 | | KK | 3.23% | 5% | 0.51 (0.17-1.57) | 0.243 | | EK+KK | 35.9% | 37% | 1.16 (0.71-1.89) | 0.561 |
|
|---|
| Reference | Benrahma H, Charoute H, Lasram K, Boulouiz R, Atig RK, Fakiri M, Rouba H, Abdelhak S, Barakat A.Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis.
Biochem Genet. 2014 Oct;52(9-10):430-42. |
|---|
| Gene symbol | ZFAND6 |
|---|
| Reference transcript | NM_014795.3 |
|---|
| DNA Change | g.80432222A>G |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs11634397 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 58.1% | 57.1% | Dominant: 1.20 (0.95-1.54) | 0.12 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | KLF14 |
|---|
| Reference transcript | NC_000007.13 |
|---|
| DNA Change | g.130466854A>G |
|---|
| A.A. Change | |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs972283 |
|---|
| Cases | 1193 T2D cases |
|---|
| Controls | 1055 normoglycaemic controls |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 69.2% | 70.5% | Log-additive: 0.92 (0.80-1.05) | 0.24 |
|
|---|
| Comments | polymorphism not associated with type 2 diabetes in the Moroccan sample population |
|---|
| Reference | Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs.
Diabetes Metab. 2012 Mar 29. |
|---|
| Gene symbol | ENPP1 |
|---|
| Reference transcript | NM_006208.2 |
|---|
| DNA Change | c.517A>C |
|---|
| A.A. Change | p.Lys173Gln |
|---|
| Exon/Intron | exon 6 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs1044498 |
|---|
| Cases | 503 sujects with T2D |
|---|
| Controls | 412 normoglycaemic |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| K | 628 (62.4%) | 519 (63%) | | | | Q | 519 (63%) | 305 (37%) | Recessive: 0.87 (0.60-1.27) | 0.47 | | KK | 194 (38.6%) | 168 (40.8%) | | | | KQ | 240 (47.7%) | 183 (44.4%) | | | | QQ | 69 (13.7%) | 61 (14.8%) | | |
|
|---|
| Reference | El Achhab Y, Meyre D, Bouatia-Naji N, Berraho M, Deweirder M, Vatin V, Delplanque J, Serhier Z, Lyoussi B, Nejjari C, Froguel P, Chikri M.Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population.
Diabetes Metab. 2009 Feb;35(1):37-42. |
|---|
| Gene symbol | IGF2BP2 |
|---|
| Reference transcript | NC_000003.11 |
|---|
| DNA Change | g.185511687G>T |
|---|
| A.A. Change | |
|---|
| Exon/Intron | intron 2 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs4402960 |
|---|
| Cases | 250 |
|---|
| Controls | 250 |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 55.20% | 62.34% | 1 | | | T | 47.8% | 37.66% | 1.34 (1.03-1.74) | 0.0278 | | GG | 32.58% | 36.40% | 1 | | | GT | 45.25% | 51.88% | 1.05 (0.69-1.59) | 0.833 | | TT | 22.17% | 11.72% | 2.33 (1.31-4.14) | 0.004 | | GT+TT | 67.4% | 63.6% | 1.27 (0.86-1.89) | 0.226 |
|
|---|
| Reference | Benrahma H, Charoute H, Lasram K, Boulouiz R, Atig RK, Fakiri M, Rouba H, Abdelhak S, Barakat A.Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis.
Biochem Genet. 2014 Oct;52(9-10):430-42. |
|---|
| Gene symbol | CDKAL1 |
|---|
| Reference transcript | NC_000006.11 |
|---|
| DNA Change | g.20679709A>G |
|---|
| A.A. Change | |
|---|
| Exon/Intron | intron 5 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs7756992 |
|---|
| Cases | 250 |
|---|
| Controls | 250 |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| A | 63.6% | 67.6% | 1 | | | G | 36.4% | 32.4% | 1.19 (0.919-1.54) | 0.18 | | AA | 38% | 45.2% | 1 | | | AG | 51.2% | 44.8% | 1.30 (0.89-1.91) | 0.166 | | GG | 10.8% | 10% | 1.12 (0.60-2.11) | 0.705 | | AG+GG | 62% | 54.8% | 1.26 (0.88-1.82) | 0.19 |
|
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| Reference | Benrahma H, Charoute H, Lasram K, Boulouiz R, Atig RK, Fakiri M, Rouba H, Abdelhak S, Barakat A.Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis.
Biochem Genet. 2014 Oct;52(9-10):430-42. |
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| Gene symbol | TNF |
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| Reference transcript | NM_000594.3 |
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| DNA Change | c.-488G>A (-308G>A) |
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| A.A. Change | |
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| Exon/Intron | 5' of the ATG codon |
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| Variation Type | substitution |
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| Reference SNP | rs1800629 |
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| Cases | 307 |
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| Controls | 244 |
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| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| G | 37.46% | 51.84% | 1 | | | A | 62.54% | 48.16% | 1.79 (1.41-2.28) | <0.0001 | | GG | 12.38% | 24.59% | 1 | | | GA | 50.16% | 54.51% | 1.78 (1.11-2.86) | 0.016 | | AA | 37.56% | 20.90% | 3.69 (2.16-6.28) | <0.0001 | | GA+AA | 87.62% | 75.41% | 2.30 (1.47-3.62) | <0.0001 |
|
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| Reference | Sefri H, Benrahma H, Charoute H, Lakbakbi el Yaagoubi F, Rouba H, Lyoussi B, Nourlil J, Abidi O, Barakat A.TNF A -308G>A polymorphism in Moroccan patients with type 2 diabetes mellitus: a case-control study and meta-analysis.
Mol Biol Rep. 2014 Sep;41(9):5805-11. |
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