TCF7L2

Gene name: transcription factor 7-like 2 (T-cell specific, HMG-box)
OMIM ID: 602228
Chromosome location: 10q25.2-q2

Polymorphisms

Disease/Phenotype	Diabetes mellitus, type 2 (T2DM), susceptibility to
Reference transcript	NM_001146274.1
DNA Change	c.450+33966C>T
A.A. Change
Exon/Intron	Intron
Variation Type	substitution
Reference SNP	rs7903146
Cases	1193 T2D cases
Controls	1055 normoglycaemic controls
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value T 47.6% 38.5% Log-additive: 1.47 (1.29-1.66) 4.06 ? 10− 9
Comments	Polymorphism associated with type 2 diabetes in the Moroccan sample population
Reference	Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs. Diabetes Metab. 2012 Mar 29.

---

Disease/Phenotype	Diabetes mellitus, type 2 (T2DM), susceptibility to
Reference transcript	NM_001146274.1
DNA Change	c.450+33966C>T
A.A. Change
Exon/Intron	Intron
Variation Type	substitution
Reference SNP	rs7903146
Cases	504 T2D subjects
Controls	406 normoglycemic
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value CC 140 (27.13%) 176 (42.41%) CT 277 (53.67%) 185 (44.58%) TT 99 (19.18%) 54 (13.01%)
Comments	An evident association between the TCF7L2 rs7903146 T allele and T2D. The allelic odds ratio (OR) was 1.56 [1.29?1.89] (p=2.9?10-6)
Reference	Cauchi S, El Achhab Y, Choquet H, Dina C, Krempler F, Weitgasser R, Nejjari C, Patsch W, Chikri M, Meyre D, Froguel P.TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med (Berl). 2007 Jul;85(7):777-82.

---