APOBEC3A

Gene name: apolipoprotein B mRNA editing enzyme catalytic subunit 3A
OMIM ID: 607109
Chromosome location: 22q13.1

Polymorphisms

Disease/Phenotype	Breast cancer, susceptibility to
Reference transcript	XM_005261386.1
DNA Change	c.-105+1367G>A
A.A. Change
Exon/Intron	5' of the ATG codon
Variation Type	others
Reference SNP	rs17370615
Cases	226 cases
Controls	200 healthy women
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value GG 111 (49.12%) 125 (62.50%) 1 GA 102 (45.13%) 66 (33.00%) 1.74 (1.16-2.60) 0.0068 AA 13 (5.75%) 9 (4.50%) 1.63 (0.67-3.95) 0.2826
Reference	Marouf C, Göhler S, Filho MI, Hajji O, Hemminki K, Nadifi S, Försti A. Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population. BMC Cancer. 2016 Feb 26;16:165. doi: 10.1186/s12885-016-2210-8.

---