CYP2B6

Gene name: cytochrome P450, family 2, subfamily B, polypeptide 6
OMIM ID: 123930
Chromosome location: 19q13.2

Polymorphisms

Disease/Phenotype	Leukemia, chronic myeloid
Reference transcript	NM_000767.4
DNA Change	c.516G>T
A.A. Change	p.Gln172His
Exon/Intron	exon 4
Variation Type	substitution
Reference SNP	rs3745274
Cases	48
Controls	64
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value G 42% 44.5% 1 T 58% 55.5% 1.12 (0.6-2) 0.669 GG 12.5% 12.5% 1 GT 58.3% 64.1% 1 (0.3-2.9) 0.874 TT 29.2% 23.4% 1.24 (0.3-4.5) 0.739
Reference	Kassogue Y, Quachouh M, Dehbi H, Quessar A, Benchekroun S, Nadifi S.Functional polymorphism of CYP2B6 G15631T is associated with hematologic and cytogenetic response in chronic myeloid leukemia patients treated with imatinib. Med Oncol. 2014 Jan;31(1):782.

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