Mendelian Diseases
Multifactorial Diseases
Disease A B C D E F G H I J K L M N O P Q R S T U V W X Y Z [0-9]
Gene A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Hypertension, susceptibility to

OMIM:145500
Mode of inheritance:Multifactorial
Disease classification:Diseases of the circulatory system


Polymorphisms

Gene symbolAPOA5
Reference transcriptNM_052968.4
DNA Change-1131T>C
A.A. Change
Exon/Intron5' of the ATG codon
Variation Typesubstitution
Reference SNPrs662799
Cases149
Controls134
Frequency
Allele/GenotypeFrequency in casesFrequency in controlsOR (95%CI)P-value
TT65.1%95.5%1
TC13.4%1.5%11.16 (2.46-50.69)0.002
CC21.5%3%14.20 (4.50-44.77)<0.0001
TC+CC34.9%4.5%13.20 (5.14-33.91)<0.0001
ReferenceOuatou S, Ajjemami M, Charoute H, Sefri H, Ghalim N, Rhaissi H, Benrahma H, Barakat A, Rouba H. Association of APOA5 rs662799 and rs3135506 polymorphisms with arterial hypertension in Moroccan patients.
Lipids Health Dis. 2014 Apr 1;13:60.
Gene symbolAPOA5
Reference transcriptNM_001166598.1
DNA Changec.56C>G
A.A. Changep.Ser19Trp
Exon/Intronexon 3
Variation Typesubstitution
Reference SNPrs3135506
Cases149
Controls134
Frequency
Allele/GenotypeFrequency in casesFrequency in controlsOR (95%CI)P-value
CC71.1%87.3%1
CG14.1%11.2%1.54 (0.72-3.29)0.269
GG14.8%1.5%13.75 (3.01-62.75)0.001
CG+GG28.9%12.7%2.90 (1.49-5.63)0.002
ReferenceOuatou S, Ajjemami M, Charoute H, Sefri H, Ghalim N, Rhaissi H, Benrahma H, Barakat A, Rouba H. Association of APOA5 rs662799 and rs3135506 polymorphisms with arterial hypertension in Moroccan patients.
Lipids Health Dis. 2014 Apr 1;13:60.
Gene symbolAPOA5
Reference transcriptNM_001166598.1
DNA Changec.553G>T
A.A. Changep.Gly185Cys
Exon/Intronexon 5
Variation Typesubstitution
Reference SNPrs2075291
Cases149
Controls134
Frequency
Allele/GenotypeFrequency in casesFrequency in controlsOR (95%CI)P-value
GG88.6%97%1
GT10.1%2.2%4.72 (1.28-17.35)0.020
TT1.3%0.8%1.64 (0.14-19.78)0.695
GT+TT11.4%3%3.92 (1.23-12.43)0.02
ReferenceOuatou S, Ajjemami M, Charoute H, Sefri H, Ghalim N, Rhaissi H, Benrahma H, Barakat A, Rouba H. Association of APOA5 rs662799 and rs3135506 polymorphisms with arterial hypertension in Moroccan patients.
Lipids Health Dis. 2014 Apr 1;13:60.
Gene symbolMTHFR
Reference transcriptNM_005957.4
DNA Changec.665C>T
A.A. Changep.Ala222Val
Exon/Intronexon 4
Variation Typesubstitution
Reference SNPrs1801133
Cases101 patients
Controls102 healthy controls
Frequency
Allele/GenotypeFrequency in casesFrequency in controlsOR (95%CI)P-value
C134 (66%)153 (75%)1
T68 (34%)51 (25%)1.5 (1-2.3)0.06
CC47 (46.5%)54 (52.9%)1
CT40 (39.6%)45 (44.2%)1 (0.6-1.8)1
TT14 (13.9%)3 (2.9%)5.4 (1.4-19.8)0.008
ReferenceNassereddine S, Kassogue Y, Korchi F, Habbal R, Nadifi S. Association of methylenetetrahydrofolate reductase gene (C677T) with the risk of hypertension in Morocco.
BMC Res Notes. 2015 Dec 12;8:775. doi: 10.1186/s13104-015-1772-x.