ALOX5AP

Gene name: arachidonate 5-lipoxygenase activating protein
OMIM ID: 603700
Chromosome location: 13q12.3

Polymorphisms

Disease/Phenotype	Ischemic stroke, susceptibility to
Reference transcript	NM_001204406.1
DNA Change	c.241+2284A>T (SG13S114)
A.A. Change
Exon/Intron	intron 2
Variation Type	substitution
Reference SNP	rs10507391
Cases	175 patients
Controls	201 controls
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value A 229 (65.4%) 302 (75.1%) 1 T 121 (34.6%) 100 (24.9%) 1.59 (1.16-2.19) 0.004 AA 89 (50.9%) 119 (59.2%) 1 AT 51 (29.1%) 64 (31.8%) 1.06 (0.67-1.68) 0.786 TT 35 (20.0%) 18 (9.0%) 2.57 (1.49-4.83) 0.003
Reference	Diakite B, Hamzi K, Hmimech W, Nadifi S; GMRAVC. Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 with the susceptibility of ischaemic stroke in Morocco. J Genet. 2016 Jun;95(2):303-9.

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