CYP7A1
Gene name: cytochrome P450, family 7, subfamily A, polypeptide 1
OMIM ID: 118455 Chromosome location: 8q12.1
Polymorphisms
| Disease/Phenotype | Mycobacterium tuberculosis, susceptibility to |
|---|
| Reference transcript | NM_000780.3 |
|---|
| DNA Change | c.-267C>A (-278 A>C) |
|---|
| A.A. Change | |
|---|
| Exon/Intron | 5' of the ATG codon |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs3808607 |
|---|
| Cases | 136 |
|---|
| Controls | 138 |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| A | 65% | 54% | 1 | | | C | 35% | 46% | 1.58 (1.04-2.41) | 0.025 | | AA | 43% | 28% | 1.94 (1.03-3.65) | 0.026 | | AC | 44% | 52% | | >0.05 | | CC | 13% | 20% | | >0.05 |
|
|---|
| Reference | Qrafli M, Amar Y, Bourkadi J, Ben Amor J, Iraki G, Bakri Y, Amzazi S, Lahlou O, Seghrouchni F, El Aouad R, Sadki K.
The CYP7A1 gene rs3808607 variant is associated with susceptibility of tuberculosis in Moroccan population.
Pan Afr Med J. 2014 May 1;18:1. |
|---|
| Disease/Phenotype | Mycobacterium tuberculosis, susceptibility to |
|---|
| Reference transcript | NC_000008.10 |
|---|
| DNA Change | g.59403576C>T (c.*458G>A) |
|---|
| A.A. Change | |
|---|
| Exon/Intron | 3' of the stop codon |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs8192879 |
|---|
| Cases | 136 |
|---|
| Controls | 138 |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 72.79% | 75.72% | | >0.05 | | T | 27.21% | 24.28% | | >0.05 | | CC | 50.73% | 59.42% | | >0.05 | | CT | 44.11% | 32.6% | | >0.05 | | TT | 5.14% | 7.97% | | >0.05 |
|
|---|
| Reference | Qrafli M, Amar Y, Bourkadi J, Ben Amor J, Iraki G, Bakri Y, Amzazi S, Lahlou O, Seghrouchni F, El Aouad R, Sadki K.
The CYP7A1 gene rs3808607 variant is associated with susceptibility of tuberculosis in Moroccan population.
Pan Afr Med J. 2014 May 1;18:1. |
|---|
| Disease/Phenotype | Mycobacterium tuberculosis, susceptibility to |
|---|
| Reference transcript | NC_000008.10 |
|---|
| DNA Change | g.59407065C>T |
|---|
| A.A. Change | p.Asp347Asn |
|---|
| Exon/Intron | exon 4 |
|---|
| Variation Type | substitution |
|---|
| Reference SNP | rs8192875 |
|---|
| Cases | 136 |
|---|
| Controls | 138 |
|---|
| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
|---|
| C | 100% | 100% | | >0.05 | | T | 0% | 0% | | >0.05 | | CC | 100% | 100% | | >0.05 | | CT | 0% | 0% | | >0.05 | | TT | 0% | 0% | | >0.05 |
|
|---|
| Reference | Qrafli M, Amar Y, Bourkadi J, Ben Amor J, Iraki G, Bakri Y, Amzazi S, Lahlou O, Seghrouchni F, El Aouad R, Sadki K.
The CYP7A1 gene rs3808607 variant is associated with susceptibility of tuberculosis in Moroccan population.
Pan Afr Med J. 2014 May 1;18:1. |
|---|