NOS3

Gene name: nitric oxide synthase 3 (endothelial cell)
OMIM ID: 163729
Chromosome location: 7q36.1

Polymorphisms

Disease/Phenotype	Ischemic stroke, susceptibility to
Reference transcript	NM_000603.4
DNA Change	c.894T>G
A.A. Change	p.Asp298Glu
Exon/Intron	exon 8
Variation Type	substitution
Reference SNP	rs1799983
Cases	165
Controls	182
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value G 70.3% 80.2% 1 T 29.7% 19.8% 1.71 (1.21-2.43) 0.003 GG 50.3% 64.3% 1 GT 40.0% 31.9% 1.60 (1.02-2.52) 0.040 TT 8.0% 3.8% 3.22 (1.27-8.18) 0.014 GT + TT 46.7% 35.7% 1.78 (1.16-2.73) 0.009
Reference	Diakite B, Hamzi K, Slassi I, El Yahyaoui M, El Alaoui MM, Habbal R, Sellama N; GMRAVC.G894T endothelial nitric oxide synthase polymorphism and ischemic stroke in Morocco. Meta Gene. 2014 May 7;2:349-57.

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Disease/Phenotype	Ischemic stroke, susceptibility to
Reference transcript	NM_000603.4
DNA Change	c.894T>G
A.A. Change	p.Asp298Glu
Exon/Intron	exon 8
Variation Type	substitution
Reference SNP	rs1799983
Cases	118 MI patients
Controls	184 healthy controls
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value T 170 (72,03%) 294 (79,89%) 1 G 66 (27,97%) 74 (20,11%) 1.54 (1.06-2.23) 0.001 TT 60 (50,85%) 116 (63,04%) 1 TG 50 (42,37%) 62 (33,69%) 1,55 (0,97-2,48) 0,02 GG 8 (6,78%) 6 (3,27%) 2,57 (0,87-7,52) 0,01
Reference	Hassani Idrissi H, Hmimech W, Diakite B, Korchi F, Baghdadi D, Habbal R, Nadifi S. Association of G894T eNOS, 4G/5G PAI and T1131C APOA5 polymorphisms with susceptibility to myocardial infarction in Morocco. Meta Gene. 2016 Apr 3;9:56-61. doi: 10.1016/j.mgene.2016.03.004. eCollection 2016.

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