ACE

Gene name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
OMIM ID: 106180
Chromosome location: 17q23.3

Polymorphisms

Disease/Phenotype	Coronary heart disease, susceptibility to
Reference transcript	NM_000789.3
DNA Change	Insertion/Deletion
A.A. Change
Exon/Intron	intron 16
Variation Type	indel
Reference SNP	rs1799752
Cases	141 patients (112 men and 29 women)
Controls	109 controls (52 men and 57 women)
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value D 0.8227 0.5321 p < 0.001 D/D 95 (67.38%) 36 (33.03%) D/I 42 (29.79%) 44 (40.37%) I/I 4 (2.84%) 29 (26.61%)
Comments	A significant association was foundnoted between ACE polymorphism and coronary heart disease
Reference	Bennouar N, Allami A, Laraqui A, Azeddoug H, El-Kadiri N, Benkouka F, Bendriss A, Ghannam R, Benomar A, Fellat S, Benomar M.[Apolipoprotein E and angiotensin-converting enzyme gene polymorphisms as risk factors of coronary disease]. Ann Biol Clin (Paris). 2004 May-Jun;62(3):295-304.

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