IL28B
Gene name: interleukin 28B (interferon, lambda 3)
OMIM ID: 607402 Chromosome location: 19q13.2
Polymorphisms
| Disease/Phenotype | Hepatitic C virus, susceptibility to |
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| Reference transcript | NC_000019.9 |
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| DNA Change | g.39738787C>T |
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| A.A. Change | |
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| Variation Type | substitution |
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| Reference SNP | rs12979860 |
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| Cases | 60 chronic hepatitis C patients |
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| Controls | |
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| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
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| C | 58.3% | | | |
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| Comments | CC genotype is more prevalent in patients (n=30) treated by combination, who achieved sustained viral response (SVR) (62.5%) than in nonresponders (n=30). |
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| Reference | Tajir M, Elmachad M, Kabbaj N, Laarabi FZ, Barkat A, Amrani N, Sefiani A.Frequency of IL28B rs12979860 Single-Nucleotide Polymorphism Alleles in Newborn Infants and in Patients with Chronic Hepatitis C in Morocco.
Genet Test Mol Biomarkers. 2012 Aug;16(8):981-3. |
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| Disease/Phenotype | Hepatitic C virus, susceptibility to |
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| Reference transcript | NC_000019.9 |
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| DNA Change | g.39738787C>T |
|---|
| A.A. Change | |
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| Variation Type | substitution |
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| Reference SNP | rs12979860 |
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| Cases | 232 patients chronically infected with HCV |
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| Controls | 68 subjects with spontaneous resolution |
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| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
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| C | 55.2% | 77.9% | 1 | | | T | 44.8% | 22.1% | 2.87 (1.84-4.48) | 0.00001 | | CC | 38.4% | 66.2% | 1 | | | CT | 33.6% | 23.5% | 2.46 (1.29-4.70) | 0.0543 | | TT | 28% | 10.3% | 4.69 (1.99-11.07) | 0.0017 |
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| Reference | Ezzikouri S, Alaoui R, Rebbani K, Brahim I, Fakhir FZ, Nadir S, Diepolder H, Khakoo SI, Thursz M, Benjelloun S.Genetic variation in the interleukin-28B gene is associated with spontaneous clearance and progression of hepatitis C virus in Moroccan patients.
PLoS One. 2013;8(1):e54793. |
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| Disease/Phenotype | Hepatitic C virus, susceptibility to |
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| Reference transcript | NC_000019.9 |
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| DNA Change | g.39743165T>G |
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| A.A. Change | |
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| Variation Type | substitution |
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| Reference SNP | rs8099917 |
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| Cases | 232 patients chronically infected with HCV |
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| Controls | 68 subjects with spontaneous resolution |
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| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
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| T | 83.2% | 95.6% | 1 | | | G | 16.8% | 4.4% | 4.38 (1.86-10.28) | 0.0025 | | TT | 68.1% | 91.2% | 1 | | | TG | 30.2% | 8.8% | 4.58 (1.89-11.08) | 0.0029 | | GG | 1.7% | 0% | 3.55 (0.19-66.89) | 0.2110 |
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| Reference | Ezzikouri S, Alaoui R, Rebbani K, Brahim I, Fakhir FZ, Nadir S, Diepolder H, Khakoo SI, Thursz M, Benjelloun S.Genetic variation in the interleukin-28B gene is associated with spontaneous clearance and progression of hepatitis C virus in Moroccan patients.
PLoS One. 2013;8(1):e54793. |
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