DNMT3B

Gene name: DNA (cytosine-5-)-methyltransferase 3 beta
OMIM ID: 602900
Chromosome location: 20q11.21

Polymorphisms

Disease/Phenotype	hepatocellular carcinoma, susceptibility to
Reference transcript	NM_006892.3
DNA Change	c.307-49C>T
A.A. Change
Exon/Intron	5' of the ATG codon
Variation Type	substitution
Reference SNP	rs2424913
Cases	96 cases with HCC
Controls	220 healthy controls
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value C 0.594 0.583 1 T 0.406 0.417 0.96 (0.68-1.35) 0.806 CC 32 (33.3%) 75 (33.8%) 1 TT 50 (52.1%) 109 (49.1%) 1.07 (0.63-1.83) 0.789 CT 14 (14.6%) 38 (17.1%) 0.86 (0.41?1.80) 0.697
Reference	Ezzikouri S, El Feydi AE, Benazzouz M, Afifi R, El Kihal L, Hassar M, Akil A, Pineau P, Benjelloun S.Single nucleotide polymorphism in DNMT3B promoter and its association with hepatocellular carcinoma in a Moroccan population. Infect Genet Evol. 2009 Sep;9(5):877-81.

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