CDKN2B

Gene name: cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
OMIM ID: 600431
Chromosome location: 9p21.3

Polymorphisms

Disease/Phenotype	Diabetes mellitus, type 2 (T2DM), susceptibility to
Reference transcript	NC_000009.11
DNA Change	g.22029547T>A
A.A. Change
Variation Type	substitution
Reference SNP	rs564398
Cases	1193 T2D cases
Controls	1055 normoglycaemic controls
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value T 79.9% 77.7% Log-additive: 1.16 (0.99-1.35) 0.06
Comments	Polymorphism associated with type 2 diabetes in the Moroccan sample population
Reference	Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, Salah D, Nejjari C, Labrune Y, Yengo L, Beury D, Vaxillaire M, Mahjoub T, Chikri M, Froguel P.European genetic variants associated with type 2 diabetes in North African Arabs. Diabetes Metab. 2012 Mar 29.

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