CCL2
Gene name: chemokine (C-C motif) ligand 2OMIM ID: 158105
Chromosome location: 17q12
Polymorphisms
| Disease/Phenotype | Mycobacterium tuberculosis, susceptibility to | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reference transcript | NG_012123.1 | ||||||||||||||||||||||||||||||
| DNA Change | g.2493A>G | ||||||||||||||||||||||||||||||
| A.A. Change | |||||||||||||||||||||||||||||||
| Exon/Intron | 5' of the ATG codon | ||||||||||||||||||||||||||||||
| Variation Type | substitution | ||||||||||||||||||||||||||||||
| Reference SNP | rs1024611 | ||||||||||||||||||||||||||||||
| Cases | 337 pulmonary TB patients | ||||||||||||||||||||||||||||||
| Controls | 155 healthy controls | ||||||||||||||||||||||||||||||
| Ethnic origin | cases and controls were from either Arab or Berber | ||||||||||||||||||||||||||||||
| Frequency |
| ||||||||||||||||||||||||||||||
| Comments | The genoytype GG of the MCP-1 polymorphism was significantly more prevalent in healthy controls than in TB patients. The association between the MCP-1 polymorphism and protection against PTB was found. | ||||||||||||||||||||||||||||||
| Reference | Arji N, Busson M, Iraqi G, Bourkadi JE, Benjouad A, Boukouaci W, Lahlou O, Ben Amor J, Krishnamoorthy R, Charron D, El Aouad R, Tamouza R.
The MCP-1 (CCL2) -2518 GG genotype is associated with protection against pulmonary tuberculosis in Moroccan patients. J Infect Dev Ctries. 2012 Jan 12;6(1):73-8. |