End-stage renal disease (ESRD)

Polymorphisms

Gene symbol	APOE
DNA Change
A.A. Change	[E2:ARG158CYS] [E3:CYS112 AND ARG158] [E4:CYS112ARG]
Variation Type	others
Cases	109 end-stage renal disease patients
Controls	97 healthy controls
Frequency	Allele/Genotype Frequency in cases Frequency in controls OR (95%CI) P-value e3 73% 82% 1 e2 3% 6% 0.473 (0.181-1.235) 0.093 e4 24% 12% 0.491 (0.277-0.870) 0.009 E3/E3 48% 67% 1 E2/E3 5% 10% 0.613 (0.197-1.904) 0.285 E2/E4 2% 3% 0.818 (0.132–5.074) 0.600 E3/E4 45% 20% 0.316 (0.166–0.601) <0.001
Reference	Lahrach H, Essiarab F, Timinouni M, Hatim B, El Khayat S, Er-Rachdi L, Jarir J, Kettani A, Ghalim N, Taki H, Lebrazi H, Ramdani B, Saïle R.Association of apolipoprotein E gene polymorphism with end-stage renal disease and hyperlipidemia in patients on long-term hemodialysis. Ren Fail. 2014 Nov;36(10):1504-9.

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