Mendelian Diseases
Multifactorial Diseases
Disease A B C D E F G H I J K L M N O P Q R S T U V W X Y Z [0-9]
Gene A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Hepatitic C virus, susceptibility to

OMIM:609532
Mode of inheritance:Multifactorial
Disease classification:Certain infectious and parasitic diseases


Polymorphisms

Gene symbolIL28B
Reference transcriptNC_000019.9
DNA Changeg.39738787C>T
A.A. Change
Variation Typesubstitution
Reference SNPrs12979860
Cases60 chronic hepatitis C patients
Controls
Frequency
Allele/GenotypeFrequency in casesFrequency in controlsOR (95%CI)P-value
C58.3%
CommentsCC genotype is more prevalent in patients (n=30) treated by combination, who achieved sustained viral response (SVR) (62.5%) than in nonresponders (n=30).
ReferenceTajir M, Elmachad M, Kabbaj N, Laarabi FZ, Barkat A, Amrani N, Sefiani A.Frequency of IL28B rs12979860 Single-Nucleotide Polymorphism Alleles in Newborn Infants and in Patients with Chronic Hepatitis C in Morocco.
Genet Test Mol Biomarkers. 2012 Aug;16(8):981-3.
Gene symbolIL28B
Reference transcriptNC_000019.9
DNA Changeg.39738787C>T
A.A. Change
Variation Typesubstitution
Reference SNPrs12979860
Cases232 patients chronically infected with HCV
Controls68 subjects with spontaneous resolution
Frequency
Allele/GenotypeFrequency in casesFrequency in controlsOR (95%CI)P-value
C55.2%77.9%1
T44.8%22.1%2.87 (1.84-4.48)0.00001
CC38.4%66.2%1
CT33.6%23.5%2.46 (1.29-4.70)0.0543
TT28%10.3%4.69 (1.99-11.07)0.0017
ReferenceEzzikouri S, Alaoui R, Rebbani K, Brahim I, Fakhir FZ, Nadir S, Diepolder H, Khakoo SI, Thursz M, Benjelloun S.Genetic variation in the interleukin-28B gene is associated with spontaneous clearance and progression of hepatitis C virus in Moroccan patients.
PLoS One. 2013;8(1):e54793.
Gene symbolIL28B
Reference transcriptNC_000019.9
DNA Changeg.39743165T>G
A.A. Change
Variation Typesubstitution
Reference SNPrs8099917
Cases232 patients chronically infected with HCV
Controls68 subjects with spontaneous resolution
Frequency
Allele/GenotypeFrequency in casesFrequency in controlsOR (95%CI)P-value
T83.2%95.6%1
G16.8%4.4%4.38 (1.86-10.28)0.0025
TT68.1%91.2%1
TG30.2%8.8%4.58 (1.89-11.08)0.0029
GG1.7%0%3.55 (0.19-66.89)0.2110
ReferenceEzzikouri S, Alaoui R, Rebbani K, Brahim I, Fakhir FZ, Nadir S, Diepolder H, Khakoo SI, Thursz M, Benjelloun S.Genetic variation in the interleukin-28B gene is associated with spontaneous clearance and progression of hepatitis C virus in Moroccan patients.
PLoS One. 2013;8(1):e54793.