Coronary artery disease, susceptibility to
OMIM: Mode of inheritance:Multifactorial
Disease classification:Diseases of the circulatory system
Polymorphisms
| Gene symbol | MTHFR |
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| Reference transcript | NM_005957.4 |
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| DNA Change | c.665C>T |
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| A.A. Change | p.Ala222Val |
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| Exon/Intron | exon 4 |
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| Variation Type | substitution |
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| Reference SNP | rs1801133 |
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| Cases | 210 subjects with CAD |
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| Controls | 190 Controls |
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| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
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| C | 280 (66.7%) | 287 (75.5%) | 1 | | | T | 140 (33.3%) | 93 (24.5%) | 1.54 (1.11-1.84) | 0.007 | | CC | 101 (48.1%) | 113 (59.5%) | 1 | | | CT | 78 (37.1%) | 61 (32.1%) | 1.43 (0.93-2.20) | 0.102 | | TT | 31 (14.8%) | 16 (8.4%) | 2.17 (1.12-4.20) | 0.022 |
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| Reference | Bennouar N, Allami A, Azeddoug H, Bendris A, Laraqui A, El Jaffali A, El Kadiri N, Benzidia R, Benomar A, Fellat S, Benomar M.Thermolabile methylenetetrahydrofolate reductase C677T polymorphism and homocysteine are risk factors for coronary artery disease in Moroccan population.
J Biomed Biotechnol. 2007;2007(1):80687. |
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| Gene symbol | PON1 |
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| Reference transcript | NM_000446.5 |
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| DNA Change | c.575A>G |
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| A.A. Change | p.Gln192Arg |
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| Exon/Intron | exon 6 |
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| Variation Type | substitution |
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| Reference SNP | rs662 |
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| Cases | 205 patients with ACS |
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| Controls | 100 healthy subjects |
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| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
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| Q | 71.46% (n = 293) | 75.50% (n = 151) | 1 | | | R | 28.53% (n = 117) | 24.50% (n = 49) | 1.3 (0.879-1.922) | <0.19 | | QQ | 55.12% (n = 113) | 57% (n = 56) | 1 | | | QR | 32.68% (n = 67) | 39% (n = 39) | 0.867 (0.522-1.439) | NS | | RR | 12.19% (n = 25) | 5% (n = 5) | 3.153 (1.04-9.49) | <0.041 |
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| Reference | Bounafaa A, Berrougui H, Ghalim N, Nasser B, Bagri A, Moujahid A, Ikhlef S, Camponova P, Yamoul N, Simo OK, Essamadi A, Khalil A.
Association between Paraoxonase 1 (PON1) Polymorphisms and the Risk of Acute Coronary Syndrome in a North African Population.
PLoS One. 2015 Aug 4;10(8):e0133719. doi: 10.1371/journal.pone.0133719. eCollection 2015. |
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| Gene symbol | PON1 |
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| Reference transcript | NM_000446.5 |
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| DNA Change | c.163T>A |
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| A.A. Change | p.Leu55Met |
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| Exon/Intron | exon 3 |
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| Variation Type | substitution |
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| Reference SNP | rs854560 |
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| Cases | 205 patients with ACS |
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| Controls | 100 healthy subjects |
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| Frequency | | Allele/Genotype | Frequency in cases | Frequency in controls | OR (95%CI) | P-value |
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| L | 62.68% (n = 257) | 73% (n = 146) | 1 | | | M | 37.32% (n = 153) | 27% (n = 54) | 1.61 (1.11-2.33) | 0.012 | | LL | 37.56% (n = 76) | 51% (n = 52) | 1 | | | LM | 51.22% (n = 105) | 43% (n = 42) | 1.71 (1.04-2.83) | 0.036 | | MM | 11.71% (n = 24) | 6% (n = 6) | 2.74 (1.04-7.16) | 0.04 |
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| Reference | Bounafaa A, Berrougui H, Ghalim N, Nasser B, Bagri A, Moujahid A, Ikhlef S, Camponova P, Yamoul N, Simo OK, Essamadi A, Khalil A.
Association between Paraoxonase 1 (PON1) Polymorphisms and the Risk of Acute Coronary Syndrome in a North African Population.
PLoS One. 2015 Aug 4;10(8):e0133719. doi: 10.1371/journal.pone.0133719. eCollection 2015. |
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