Database

Disease	A B C D E F G H I J K L M N O P Q R S T U V W X Y Z [0-9]
Gene	A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Obesity, susceptibility to

OMIM:601665
Mode of inheritance:Multifactorial
Disease classification:Endocrine, nutritional and metabolic disease

Polymorphisms

Gene symbol

ENPP1

Reference transcript

NM_006208.2

DNA Change

c.517A>C

A.A. Change

p.Lys173Gln

Exon/Intron

exon 6

Variation Type

substitution

Reference SNP

rs1044498

Cases

259 Obese

Controls

656 Non-Obese

Frequency

Allele/Genotype	Frequency in cases	Frequency in controls	OR (95%CI)	P-value
K	302 (58.3%)	845 (64.4%)
Q	216 (41.7%)	467 (35.6%)	Recessive: 1.91 (1.27-2.85)	0.002
KK	93 (35.9%)	269 (41%)
KQ	116 (44.8%)	307 (46.8%)
QQ	50 (19.3%)	80 (12.2%)

Reference

El Achhab Y, Meyre D, Bouatia-Naji N, Berraho M, Deweirder M, Vatin V, Delplanque J, Serhier Z, Lyoussi B, Nejjari C, Froguel P, Chikri M.Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population.
Diabetes Metab. 2009 Feb;35(1):37-42.

Gene symbol

APOA5

Reference transcript

NM_052968.4

DNA Change

-1131T>C

A.A. Change

Exon/Intron

5' of the ATG codon

Variation Type

substitution

Reference SNP

rs662799

Cases

164 obeses

Controls

295 non-obeses

Frequency

Allele/Genotype	Frequency in cases	Frequency in controls	OR (95%CI)	P-value
TT	77 (47.8%)	20 (12.4%)	1
TC	64 (39.8%)	90 (30.9%)	1.69 (1.10-2.62)	0.017
CC	20 (12.4%)	13 (4.5%)	4.13 (1.86-9.03)	<0.0001

Reference

Lakbakbi El Yaagoubi F, Charoute H, Bakhchane A, Ajjemami M, Benrahma H, Errouagui A, Kandil M, Rouba H, Barakat A. Association analysis of APOA5 rs662799 and rs3135506 polymorphisms with obesity in Moroccan patients.
Pathol Biol (Paris). 2015 Dec;63(6):243-7. doi: 10.1016/j.patbio.2015.09.002.

Gene symbol

APOA5

Reference transcript

NM_001166598.1

DNA Change

c.56C>G

A.A. Change

p.Ser19Trp

Exon/Intron

exon 3

Variation Type

substitution